Rewarming of healthy volunteers after induced mild hypothermia: a healthy volunteer study

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Rewarming of healthy volunteers after induced mild hypothermia: a healthy volunteer study.

OBJECTIVES The study compares the efficacy of two active and one passive warming interventions in healthy volunteers with induced mild hypothermia. METHODS Eight volunteers were studied in a random order crossover design. Each volunteer was studied during re-warming from a core temperature of 35 degrees C with each of: a radiant warmer (Fisher & Paykel); a forced air warmer (Augustine Medical...

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The clinical use of therapeutic hypothermia has been rapidly expanding due to evidence of neuroprotection. However, the effect of hypothermia on specific pathways of drug elimination in humans is relatively unknown. To gain insight into the potential effects of hypothermia on drug metabolism and disposition, we evaluated the pharmacokinetics of midazolam as a probe for CYP3A4/5 activity during ...

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ژورنال

عنوان ژورنال: Emergency Medicine Journal

سال: 2005

ISSN: 1472-0205,1472-0213

DOI: 10.1136/emj.2003.007963